Lone Survivor is a post-apocalyptic survival horror video game with pixel graphics. Players take control of an unnamed young man in a surgical mask who's become isolated in his apartment complex after the outbreak of a strange virus. This virus turns the world's population into aggressive, shambling mutants.
The player character must be guided outside of his apartment to scavenge for food and explore. When exploring the environment, the player character must collect food, items, keys, and more. Two way mirrors can be used to teleport between two areas. Weapons can be found to defeat monsters, but ammunition is scarce. Players can utilize stealth to sneak past enemies while in the shadows.
Players must sleep periodically to prevent the main character from losing his mind, and pills can be taken to help facilitate the sleep process. The player's interactions with the game world and it's character result in different endings upon the completion of the game.
A nameless man in a surgical mask (referred to in the game as 'You') has been living in an apartment for an unspecified amount of time, after a disease has turned most of the world's inhabitants into mindless, zombie-like monsters. The man has periodic dreams featuring a bizarre cast of characters, including a Man Who Wears a Box and a young girl in a blue dress.
In the waking world, the man is out of supplies and is forced to explore for food, weapons, and other survivors. Following leads picked up from his radio, annotated maps, and discarded diary entries, the man explores his apartment complex with the goal to discover what the true state of the world is in.